From Book News, Inc.
A naturally occurring metabolite of the inhibitory neurotransmitter GABA, gamma-hydroxybutyrate (GHB) is being investigated for its efficacy in treating sleep disorders, fibromyalgia, and drug addiction. Its euphoric and sleep-inducing effects have unfortunately also led to its abuse as a "date rape drug." Aimed at neurobiologists and clinicians, this volume contains 14 contributions from international researchers on the biochemistry, physiology, and pharmacology of GHB in the central nervous system. Tunnicliff teaches at Indiana U. School of Medicine and Cash is with CNRS in Strasbourg, France.Copyright © 2004 Book News, Inc., Portland, OR
Book Description
Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state, and from its use in general anaesthesia in human subjects. Soon it was found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This opened up a completely new line of research in an effort to establish a function for GHB. This book has brought together the combined expertise of many of the leading authorities on the biochemistry, physiology and pharmacology of GHB in the central nervous system. Each chapter is an in-depth review of the field and the book itself will appeal to all neurobiologists interested in neurotransmitter mechanisms, as well as to clinicians and other health-care workers interested in this fascinating chemical.
Book Info
Indiana Univ., Evansville. Text combines the expertise of leading authorities in biochemistry, physiology, and pharmacology of GHB (gamma-hydroxybutyrate) in the central nervous system. The many pharmacological uses of GHB, as well as its misuses, are explored. Abundant halftone illustrations.
About the Author
Godfrey Tunnicliff is with the Indiana University School of Medicine in the USA and Cristopher D. Cash is with CNRS in Strasbourgh, France Rating
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