Release Date: 01 April, 2003
Hardcover
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From Book News, Inc.
Originally derived from the North American yew tree in 1971, taxoid paclitaxel (trade name Taxol) has become an important therapeutic agent in the treatment of cancer. In this volume, 12 contributions from researchers working in the US, UK, and Japan present detailed coverage of a variety of areas in taxoid science. Topics include, for example, the biosynthesis of taxoids, the commercial cultivation of Taxus species, and the clinical applications of the taxanes. The editors (and a number of the contributors) are affiliated with the U. of North Carolina at Chapel Hill.Copyright © 2004 Book News, Inc., Portland, OR
Book Description
Taxol is a well-known anticancer agent worldwide. Mechanistically, it has a unique microtuble stabilizing activity, and was clinically developed as an important new therapeutic agent in the treatment of breast and ovarian cancers at the National Cancer Institute, Washington D.C.. In this current book, the authors will concentrate on taxoids from their occurrence in clinical studies, including chemistry, physical methods for structure identification, structure-activity relationships, biosynthesis, plant tissue culture, pre-clinical investigation, analytical aspects, and commercial cultivation. In particular, taxoid synthesis will be explained in considerable detail. This volume includes a thorough review of the key literature, as well as data from scientists who are engaged in current taxoid research. It will be of great value to anyone wishing to gain a broad perspective on taxoid research and development.
Book Info
Univ. of North Carolina, Chapel Hill. Text provides an authoritative account of the taxoids. Covers production and biosynthesis, from commercial cultivation to plant tissue culture methods. Describes taxoid chemistry and reviews data from current taxoid research as a anticancer agent. For researchers.
About the Author
Hideji Itokawa and Kuo-Hsiung Lee, are both at the University of North Carolina at Chapel Hill the USA. Rating
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