Release Date: 01 May, 1999
Hardcover
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Book News, Inc.
The collection of 23 contributions demonstrates how process chemists translate a laboratory method for making an organic chemical on a milligram scale into a production process on a kilogram to ton scale. The volume opens with an overview of the subject and a process research and development strategy for accelerated projects. Twelve case studies on agents such as inhibitors and antagonists provide detailed accounts of the processes to synthesize a drug substance from the exploratory level to manufacturing stage. The remaining papers discuss enzymatic intervention and phase transfer catalysis, asymmetric synthesis and enantioselectivity, drug substance final form and process safety, and the design of experiments and automation. -- Copyright © 1999 Book News, Inc., Portland, OR All rights reserved
European Journal of Pharmaceutics and Biopharmaceutics, 2000
"...presents pharmaceutical synthesis at its best in a very concise and educational way."
Book Info
Bristol-Myers Squibb Co., New Brunswick, NJ. Reference highlights new strategies for aggressive drug development programs. Includes 12 case studies on agents such as inhibitors and antagonists, 'green chemistry', and new medicinal compounds. For chemists and those entering pharmaceutical discover and development fields. Illustrated. Rating
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